DSIP¶

Identification¶

Property	Value
CAS Number	62568-57-4
Molecular Formula	C₃₅H₄₈N₁₀O₁₅
Molecular Weight	~848.8 Da
Sequence	Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
Amino Acid Count	9
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Soluble in sterile water or PBS
Storage	2–8°C, desiccated, protect from light

Category: Nootropic & Anti-Aging

Catalog SKU: PSH-DSIP-5MG

Research Background¶

DSIP (Delta Sleep-Inducing Peptide) was first isolated from rabbit cerebral venous blood during electrically-induced sleep in the 1970s by Monnier and Schoenenberger. The isolated nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) was found to induce slow-wave (delta) sleep. Subsequent research expanded its profile beyond sleep: it modulates the HPA stress axis, produces opioid-independent analgesia, and influences circadian regulation.

Key Mechanisms¶

Mechanism	Details
Delta Wave Induction	Slow-wave (0.5–4 Hz) EEG activity promotion → restorative sleep architecture
HPA Axis Modulation	Reduced ACTH release → lower corticosterone; stress axis dampening
Opioid-Independent Analgesia	Pain threshold elevation without μ-opioid receptor activation
Neurotransmitter Balance	Modulation of serotonin, GABA, and glutamate in sleep-regulating nuclei

Research Focus Areas¶

Delta Sleep Promotion¶

Slow-wave sleep enhancement; sleep efficiency improvement

Circadian Rhythm¶

Sleep-wake cycle regulation in jet lag and shift work models

Stress Response¶

ACTH and corticosterone modulation under stress conditions

Pain Modulation¶

Opioid-independent analgesic effects in chronic pain models

Available Configurations¶

Configuration	Content	Best For
Standard Kit	5 mg × 10 vials	Sleep research; evaluation
Bulk Kit	10 mg × 10 vials	Chronic sleep models; repeat orders
Custom	Custom mg × custom vials	OEM; private-label

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~848.8 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: What is Delta Sleep-Inducing Peptide (DSIP)?¶

DSIP is a naturally occurring nonapeptide first isolated from rabbit cerebral blood during induced slow-wave sleep. It promotes delta wave (0.5–4 Hz) EEG activity characteristic of deep, restorative sleep. Also modulates HPA stress axis and produces opioid-independent analgesia.

Q2: How was DSIP discovered?¶

Discovered in the 1970s by Monnier and Schoenenberger, who electrically stimulated rabbit thalamus to induce sleep, collected cerebral venous blood, and isolated the factor that transferred sleep-inducing activity to recipient animals. Identified as the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.

Q3: Does DSIP work through opioid receptors?¶

No — a key research distinction. DSIP produces analgesic effects but does not bind μ, δ, or κ opioid receptors. Its analgesic mechanism involves central serotonin and GABA pathways. This opioid-independent pain modulation makes it a unique research tool.

Q4: How does DSIP compare to melatonin for sleep research?¶

Melatonin primarily regulates sleep timing (circadian phase shifting). DSIP primarily affects sleep depth (delta wave promotion). Different aspects of sleep physiology — can be studied in complementary protocols.

Q5: What purity and QC is provided for DSIP?¶

≥99% HPLC with ESI-MS identity. Trp¹ residue monitored for oxidation. Batch-specific COA included. Full analytical documentation for bulk orders.

Key Research References¶

Reference	PMID	Key Finding
Monnier M & Schoenenberger GA. "Characterization of a delta-electroencephalogram (-sleep)-inducing peptide." Proc Natl Acad Sci USA. 1977;74(3):1282–1286.	265572	Original isolation and characterization: DSIP induces slow-wave (delta) EEG activity; identified as nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Pollmächer T & Schulz H. "Delta sleep-inducing peptide (DSIP): a still unresolved riddle." J Sleep Res. 2006;15(2):166–173.	16539679	Comprehensive review of DSIP pharmacology including HPA axis modulation, opioid-independent analgesia, and circadian effects

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	Standard peptide stability; 24 months at 2–8°C in desiccated environment, protect from light
Neutral pH (6.0–7.5)	Stable; recommended for reconstitution in sterile water or PBS
Trp¹ Oxidation	N-terminal tryptophan residue is oxidation-sensitive; protect from direct light and oxidants. Verified by HPLC-MS (Met(O) content monitored)
Reconstituted Solution	24 h at 2–8°C; aliquot and freeze at −20°C for extended use. Avoid repeated freeze-thaw

Source & Purchase¶

For research-grade DSIP and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

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