Ipamorelin¶

Identification¶

Property	Value
CAS Number	170851-70-4
Molecular Formula	C₃₈H₄₉N₉O₅
Molecular Weight	~711.9 Da
Sequence	Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Amino Acid Count	5 (Aib¹, D-2-Nal³, D-Phe⁴ modified)
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Soluble in sterile or bacteriostatic water
Storage	2–8°C, desiccated, protect from light

Category: Muscle Growth

Catalog SKU: PSH-IPAM-2MG

Research Background¶

Ipamorelin is a synthetic pentapeptide GH secretagogue that selectively activates the ghrelin receptor (GHS-R1a). What distinguishes it from earlier GHS peptides is receptor selectivity — it produces a clean GH pulse with minimal activation of ACTH/cortisol, prolactin, or hunger-signaling pathways. This selectivity is achieved through strategic incorporation of non-proteinogenic amino acids: Aib at position 1, D-2-Nal at position 3, and D-Phe at position 4.

Key Mechanisms¶

Mechanism	Details
GHS-R1a Agonism	Selective ghrelin receptor activation on pituitary somatotrophs → GH release
Somatostatin Suppression	GHS-R activation reduces hypothalamic somatostatin tone → permissive GH secretion
Minimal Off-Target	Unlike GHRP-2/GHRP-6, Ipamorelin does not significantly activate ACTH/cortisol or hunger pathways

Research Focus Areas¶

Selective GH Release¶

Clean GH pulse with minimal prolactin, ACTH, or cortisol elevation

GH Secretagogue Research¶

GHS-R1a pharmacology — receptor selectivity profiling

Body Composition¶

Lean mass preservation in caloric deficit models

Combination Protocols¶

Synergistic GH elevation with GHRH analogues (CJC-1295)

Available Configurations¶

Configuration	Content	Best For
Standard Kit	2 mg × 10 vials	GH pulse studies; evaluation
Bulk Kit	5 mg × 10 vials	Chronic protocols; repeat orders
Custom	Custom mg × custom vials	OEM; private-label

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~711.9 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Chiral Purity	Chiral HPLC	≥99% (Aib, D-2-Nal, D-Phe verified)
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: What makes Ipamorelin different from GHRP-2/GHRP-6?¶

Selectivity. Ipamorelin is the most selective ghrelin receptor agonist of the GHRP family. At research concentrations, it produces GH release without significant ACTH, cortisol, prolactin, or hunger elevation. GHRP-2/6 are more potent GH releasers but with broader receptor profiles.

Q2: Why is Ipamorelin paired with CJC-1295?¶

CJC-1295 provides the GHRH signal (the 'on' switch). Ipamorelin suppresses somatostatin tone (the 'off' switch). Together they produce synergistic GH pulse — the most studied GH secretagogue protocol in preclinical research.

Q3: What are the unique amino acid modifications?¶

Aib (α-aminoisobutyric acid) at position 1 for protease resistance; D-2-Nal at position 3 for GHS-R binding selectivity; D-Phe at position 4 to further refine selectivity. Confirmed by chiral HPLC in every batch.

Q4: How does Ipamorelin affect appetite vs GHRP-6?¶

Minimally. GHRP-6 is a potent ghrelin mimetic that strongly activates hunger signaling. Ipamorelin was specifically designed to reduce this off-target effect while maintaining GH release.

Q5: What purity and QC documentation is provided?¶

≥99% HPLC purity, ESI-MS identity, and chiral HPLC verification of D-amino acid content. Batch-specific COA included.

Key Research References¶

Reference	PMID	Key Finding
Raun K et al. "Ipamorelin, the first selective growth hormone secretagogue." Eur J Endocrinol. 1998;139(5):552–561.	9849822	Ipamorelin characterized as the most selective GHS-R1a agonist; produces clean GH pulse with minimal ACTH/cortisol, prolactin, or hunger activation
Johansen PB et al. "Ipamorelin, a new growth hormone secretagogue, increases longitudinal bone growth in rats." Growth Horm IGF Res. 1999;9(2):106–113.	10373343	Ipamorelin increased GH pulsatility and longitudinal bone growth in rodent models, demonstrating anabolic effects of selective GHS-R agonism

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	24 months at 2–8°C in desiccated environment, protect from light
Non-Proteinogenic Amino Acids	Aib¹, D-2-Nal³, and D-Phe⁴ provide protease resistance and enhanced solution stability
Neutral pH (6.0–7.5)	Stable; recommended for reconstitution in sterile or bacteriostatic water
Reconstituted Solution	24 h at 2–8°C; aliquot and freeze at −20°C. Modified amino acids provide good solution stability. Avoid freeze-thaw cycles

Source & Purchase¶

For research-grade IPAMORELIN and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

Browse IPAMORELIN & Related Products →

Product	Link
CJC-1295 (no DAC)	cjc-1295-no-dac.md — Pulsatile GHRH analogue
CJC-1295 (DAC)	cjc-1295-dac.md — Long-acting GHRH analogue
GHRP-2 (Pralmorelin)	ghrp-2.md — Potent ghrelin receptor agonist
HGH (Somatropin)	hgh.md — 191-aa human growth hormone