GHRP-6¶

Identification¶

Property	Value
CAS Number	87616-84-0
Molecular Formula	C₄₆H₅₆N₁₂O₆
Molecular Weight	~873.0 Da
Sequence	His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
Amino Acid Count	6 (D-Trp², D-Phe⁵)
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Soluble in sterile or bacteriostatic water
Storage	2–8°C, desiccated, protect from light

Category: Muscle Growth

Catalog SKU: PSH-GHRP6-5MG

Research Background¶

GHRP-6 is the prototypical synthetic ghrelin receptor agonist — and the most orexigenic member of the GHRP family. Its hexapeptide sequence (His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂) closely mimics the N-terminal active core of ghrelin, producing potent activation of both the GH-releasing and appetite-stimulating arms of GHS-R1a signaling.

Key Mechanisms¶

Mechanism	Details
GHS-R1a Agonism	Potent ghrelin receptor activation → GH release + appetite signaling
NPY/AgRP Activation	GHS-R activation in hypothalamic arcuate nucleus → NPY/AgRP neurons → hunger
GI Motility	Ghrelin mimetic activity on enteric neurons → gastric emptying and motility

Research Focus Areas¶

GH Release¶

Potent pituitary GH secretion via ghrelin receptor activation

Appetite Research¶

Strong orexigenic (hunger-promoting) signaling — ghrelin pathway studies

Gastric Motility¶

Ghrelin-mediated GI motility and gastric emptying research

Body Composition¶

GH/IGF-1 mediated anabolic effects with appetite co-stimulation

Available Configurations¶

Configuration	Content	Best For
Standard Kit	5 mg × 10 vials	Ghrelin pathway research; evaluation
Bulk Kit	10 mg × 10 vials	Chronic protocols; repeat orders
Custom	Custom mg × custom vials	OEM; private-label

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~873.0 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Chiral Purity	Chiral HPLC	D-Trp², D-Phe⁵ verified
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: Why does GHRP-6 increase hunger so strongly?¶

GHRP-6 is the closest structural mimetic to ghrelin's N-terminal active core. Its activation of GHS-R1a in the hypothalamic arcuate nucleus strongly stimulates NPY/AgRP neurons — the most potent orexigenic neurons in the brain.

Q2: How does GHRP-6 compare to GHRP-2?¶

Both are potent GHS-R1a agonists, but GHRP-6 produces stronger hunger signaling due to closer structural homology to ghrelin. GHRP-2 has modifications (D-Ala¹, D-2-Nal²) that shift toward purer GH release with less appetite stimulation.

Q3: Is GHRP-6 suitable for all GH research?¶

It depends on protocol. GHRP-6 is the tool of choice when studying ghrelin's dual GH-releasing and appetite-stimulating effects. When appetite is a confounding variable, Ipamorelin (minimal hunger) or GHRP-2 (moderate hunger) should be considered.

Q4: What is the structural basis of GHRP-6 activity?¶

D-Trp² and D-Phe⁵ residues are critical for GHS-R1a binding and stability. His¹ mimics ghrelin's N-terminal serine-3 acylation site. Together these enable nanomolar potency while resisting degradation.

Q5: How should GHRP-6 be stored?¶

Lyophilized: 2–8°C, desiccated, 24-month stability. Reconstitute, aliquot, store at -20°C. D-amino acid modifications provide good solution stability. Protect from freeze-thaw cycles.

Key Research References¶

Reference	PMID	Key Finding
Bowers CY et al. "On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone." Endocrinology. 1984;114(5):1537–1545.	6714155	Original characterization of GHRP-6 as the prototypical synthetic ghrelin receptor agonist; GHS-R1a agonism as a new mechanism for GH release
Kojima M et al. "Ghrelin is a growth-hormone-releasing acylated peptide from stomach." Nature. 1999;402(6762):656–660.	10604470	Discovery of ghrelin as the endogenous GHS-R ligand; provided structural basis for GHRP-6's orexigenic and GH-releasing activities

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	24 months at 2–8°C in desiccated environment, protect from light
D-Amino Acid Stability	D-Trp² and D-Phe⁵ provide resistance to enzymatic degradation; extended solution stability vs all-L peptides
Neutral pH (6.0–7.5)	Stable; recommended for reconstitution in sterile or bacteriostatic water
Reconstituted Solution	24 h at 2–8°C; aliquot and freeze at −20°C. D-amino acid backbone provides good solution stability. Avoid freeze-thaw cycles

Source & Purchase¶

For research-grade GHRP 6 and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

Browse GHRP 6 & Related Products →

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