Snap-8¶

Identification¶

Property	Value
CAS Number	— (Acetyl Octapeptide-3)
Molecular Formula	C₄₁H₇₀N₁₆O₁₆S
Molecular Weight	~1,073.2 Da
Sequence	Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
Amino Acid Count	8 (N-terminal acetyl, C-terminal amide)
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Soluble in sterile water; cosmetic formulation-compatible
Storage	2–8°C, desiccated, protect from light

Category: Cosmetic & Skin

Catalog SKU: PSH-SNAP8-10MG

Research Background¶

Snap-8 (Acetyl Octapeptide-3) is an N-terminal acetylated, C-terminal amidated octapeptide designed to interfere with SNARE complex assembly at the presynaptic membrane. By mimicking the N-terminal domain of SNAP-25 — a critical SNARE protein — Snap-8 competes for binding sites within the ternary SNARE complex (SNAP-25/syntaxin/VAMP). This competition reduces the efficiency of synaptic vesicle docking and fusion, leading to decreased acetylcholine release at the neuromuscular junction.

Key Mechanisms¶

Mechanism	Details
SNAP-25 Competition	Mimics N-terminal domain of SNAP-25 → competes for SNARE complex binding
Vesicle Docking Inhibition	Reduced ternary SNARE complex formation → decreased synaptic vesicle fusion
ACh Release Reduction	Less acetylcholine released at neuromuscular junction → muscle fiber relaxation

Research Focus Areas¶

Expression Lines¶

SNARE complex inhibition → reduced neurotransmitter release at NMJ

Crow's Feet¶

Periorbital wrinkle reduction in topical formulation models

Forehead Lines¶

Frontalis muscle relaxation via SNAP-25 competition

Anti-Wrinkle Formulations¶

Topical peptide delivery systems for cosmetic research

Available Configurations¶

Configuration	Content	Best For
Standard Kit	10 mg × 10 vials	Formulation research; evaluation
Bulk Kit	50 mg × 10 vials	Product development; pilot batches
Custom	Custom mg × custom vials	OEM; private-label cosmetics

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~1,073.2 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: How does Snap-8 work in anti-wrinkle research?¶

Snap-8 mimics the N-terminal domain of SNAP-25, a protein essential for SNARE complex assembly. By competing with native SNAP-25, it reduces synaptic vesicle docking efficiency → less ACh released at NMJ → muscle fibers relax → expression lines reduced in topical research.

Q2: How does Snap-8 differ from Argireline?¶

Both target neurotransmitter release through different mechanisms. Argireline prevents formation of the ternary SNARE complex. Snap-8 specifically targets the SNAP-25 binding site within the complex. In research they are sometimes combined for multi-target effects.

Q3: Is Snap-8 stable in topical formulations?¶

Yes. N-terminal acetylation and C-terminal amidation enhance metabolic stability and skin penetration. Soluble in standard cosmetic base formulations at pH 5.0–7.0.

Q4: Can Snap-8 and Leuphasyl be used together?¶

Yes — this is a common research combination. Snap-8 targets SNARE complex assembly, while Leuphasyl acts through opioid receptor-mediated calcium channel modulation. Complementary mechanisms.

Q5: What is the standard purity for Snap-8?¶

≥99% by HPLC with ESI-MS identity. Batch-specific COA included. For cosmetic-grade bulk orders, lower purity grades may be available — contact us for specifications.

Key Research References¶

Reference	PMID	Key Finding
Blanes-Mira C et al. "Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis." J Neurochem. 2004;88(1):124–135.	14675156	Snap-8 design and mechanism: mimics SNAP-25 N-terminal domain to inhibit ternary SNARE complex assembly, reducing ACh release
Gorouhi F & Maibach HI. "Role of topical peptides in preventing or treating aged skin." Int J Cosmet Sci. 2009;31(5):327–345.	19570099	Review of cosmetic peptides including Snap-8; mechanism as SNAP-25 competitor for anti-wrinkle research vs botulinum toxin

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	Standard peptide stability; 24 months at 2–8°C in desiccated environment, protect from light
N-Terminal Acetylation	Acetyl cap protects against aminopeptidase degradation; C-terminal amidation protects against carboxypeptidase
Neutral pH (5.0–7.0)	Stable; compatible with cosmetic formulation conditions at standard pH
Reconstituted Solution	24 h at 2–8°C; aliquot and freeze at −20°C for extended use. Met⁵ residue susceptible to oxidation — protect from oxidative conditions

Source & Purchase¶

For research-grade SNAP 8 and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

Browse SNAP 8 & Related Products →

Product	Link
Argireline (Acetyl Hexapeptide-8)	argireline.md — SNARE complex inhibitor
Leuphasyl (Pentapeptide-18)	leuphasyl.md — δ-opioid receptor agonist for fine lines
Matrixyl (Palmitoyl Pentapeptide-4)	matrixyl.md — Matrikine signaling for collagen synthesis
GHK-Cu (Copper Tripeptide)	ghk-cu.md — Copper peptide for wound healing