GHRP-2¶

Identification¶

Property	Value
CAS Number	158861-67-7
Molecular Formula	C₄₅H₅₅N₉O₆
Molecular Weight	~817.0 Da
Sequence	D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
Amino Acid Count	6 (D-Ala¹, D-2-Nal², D-Phe⁵)
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Soluble in sterile or bacteriostatic water
Storage	2–8°C, desiccated, protect from light

Category: Muscle Growth

Catalog SKU: PSH-GHRP2-5MG

Research Background¶

GHRP-2 (also known as Pralmorelin) is a synthetic hexapeptide ghrelin receptor agonist. It is one of the most potent GH secretagogues in the GHRP family, producing a rapid, robust GH pulse. Developed through structure-activity relationship studies of met-enkephalin derivatives, GHRP-2 features D-amino acid modifications (D-Ala¹, D-2-Nal², D-Phe⁵) that confer both metabolic stability and high receptor affinity.

Key Mechanisms¶

Mechanism	Details
GHS-R1a Agonism	Potent ghrelin receptor activation → PLC → IP₃ → Ca²⁺ mobilization → GH exocytosis
GHRH Potentiation	GHS-R and GHRH-R signaling converge on somatotroph → synergistic cAMP/Ca²⁺ response
Somatostatin Antagonism	GHS-R activation reduces hypothalamic somatostatin release → permissive GH secretion

Research Focus Areas¶

GH Pulse Induction¶

Rapid, potent GH release via GHS-R1a activation on pituitary

Pulsatile GH Research¶

Sharp GH spikes — compatible with post-exercise window protocols

Appetite Signaling¶

Ghrelin pathway activation — feeding behavior studies

IGF-1 Axis¶

GH-mediated hepatic IGF-1 production cascade

Available Configurations¶

Configuration	Content	Best For
Standard Kit	5 mg × 10 vials	GH pulse research; evaluation
Bulk Kit	10 mg × 10 vials	Chronic protocols; repeat orders
Custom	Custom mg × custom vials	OEM; private-label

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~817.0 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Chiral Purity	Chiral HPLC	D-amino acids verified
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: How potent is GHRP-2 vs other GH secretagogues?¶

GHRP-2 is among the most potent GHS-R1a agonists, producing GH elevations exceeding GHRP-6 and Ipamorelin at equivalent doses. However, this potency comes with broader receptor profile including stronger appetite stimulation.

Q2: What distinguishes GHRP-2 from Ipamorelin?¶

GHRP-2: more potent GH release, stronger hunger signaling, potential cortisol elevation. Ipamorelin: cleaner GH pulse, minimal hunger, minimal cortisol. Choice depends on whether maximum amplitude or receptor selectivity is the priority.

Q3: What is the origin of GHRP-2?¶

GHRP-2 (Pralmorelin) was developed by Kaken Pharmaceutical in Japan through systematic modification of met-enkephalin derivatives. D-amino acid substitutions provide enzymatic resistance while maintaining high GHS-R1a binding affinity.

Q4: How should GHRP-2 be stored?¶

Lyophilized: 2–8°C, desiccated, 24-month stability. After reconstitution, aliquot and store at -20°C. Avoid freeze-thaw cycles. D-amino acid modifications provide good solution stability.

Q5: Can GHRP-2 be combined with CJC-1295?¶

Yes — common research combination. CJC-1295 provides sustained GHRH signal; GHRP-2 provides potent ghrelin receptor pulse. CJC-1295 (no DAC) + GHRP-2 is particularly suited for pulsatile GH protocol research.

Key Research References¶

Reference	PMID	Key Finding
Bowers CY et al. "On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone." Endocrinology. 1984;114(5):1537–1545.	6714155	Original characterization of GHRP family hexapeptides; GHRP-2 (Pralmorelin) identified as potent GHS-R1a agonist with D-amino acid modifications
Hataya Y et al. "A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans." J Clin Endocrinol Metab. 2001;86(9):4552–4555.	11549707	Ghrelin/GHRP synergism with GHRH demonstrated; mechanism for CJC-1295 + GHRP combination protocols

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	24 months at 2–8°C in desiccated environment, protect from light
D-Amino Acid Stability	D-Ala¹, D-2-Nal², and D-Phe⁵ substitutions confer resistance to enzymatic degradation; enhanced stability in reconstituted solution compared to all-L peptides
Neutral pH (6.0–7.5)	Stable; recommended for reconstitution in sterile or bacteriostatic water
Reconstituted Solution	24 h at 2–8°C; aliquot and store at −20°C. D-amino acid modifications provide good solution stability. Avoid freeze-thaw cycles

Source & Purchase¶

For research-grade GHRP 2 and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

Browse GHRP 2 & Related Products →

Product	Link
Ipamorelin	ipamorelin.md — Selective GHS-R1a agonist
GHRP-6	ghrp-6.md — Ghrelin mimetic with strong orexigenic effects
CJC-1295 (no DAC)	cjc-1295-no-dac.md — Pulsatile GHRH analogue
HGH (Somatropin)	hgh.md — 191-aa human growth hormone