Selank¶

Identification¶

Property	Value
CAS Number	129954-34-1
Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight	~751.9 Da
Sequence	Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH
Amino Acid Count	7 (tuftsin analogue + Pro-Gly-Pro)
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Soluble in sterile water or PBS
Storage	2–8°C, desiccated, protect from light

Category: Nootropic & Anti-Aging

Catalog SKU: PSH-SELANK-10MG

Research Background¶

Selank is a synthetic heptapeptide sharing the same Pro-Gly-Pro C-terminal extension design as Semax. While Semax derives from ACTH, Selank derives from tuftsin (Thr-Lys-Pro-Arg) — a natural immunomodulatory tetrapeptide. The Pro-Gly-Pro tail transforms tuftsin from a pure immune peptide into a dual-function molecule engaging the immune-neural interface while enabling CNS penetration. Selank's primary research application is anxiolysis through GABAergic and dopaminergic modulation — producing anxiety reduction without sedation, cognitive impairment, or dependence liability.

Key Mechanisms¶

Mechanism	Details
GABAergic Modulation	Positive modulation of GABA-A receptor function → anxiolysis without sedation
Dopaminergic System	Modulation of dopamine turnover → cognitive preservation under stress
Immune Modulation	Tuftsin-derived Thr-Lys-Pro-Arg motif → macrophage/neutrophil activation
C-terminal PGP	Pro-Gly-Pro extension → enhanced stability and BBB penetration (shared with Semax)

Research Focus Areas¶

Anxiolysis¶

GABAergic modulation — anxiety reduction without sedation in models

Cognitive Function¶

Learning & memory preservation under stress conditions

Immune-Neural Bridge¶

Tuftsin-derived immunomodulation → CNS effects

Stress Resilience¶

HPA axis modulation; cortisol reduction in stress models

Antiviral Research¶

Tuftsin-mediated immune enhancement against viral challenges

Available Configurations¶

Configuration	Content	Best For
Standard Kit	10 mg × 10 vials	Anxiolytic research; evaluation
Bulk Kit	30 mg × 10 vials	Chronic anxiety models; repeat orders
Custom	Custom mg × custom vials	OEM; private-label

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~751.9 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: How does Selank compare to benzodiazepines?¶

Selank produces anxiolytic effects through GABAergic modulation without sedation, amnesia, tolerance, or withdrawal. Rather than directly agonizing GABA-A, Selank modulates endogenous GABA tone — a more subtle mechanism preserving cognitive function and alertness.

Q2: What is the connection between tuftsin and Selank?¶

Tuftsin (Thr-Lys-Pro-Arg) is a natural splenic tetrapeptide that activates macrophages. Selank adds Pro-Gly-Pro to tuftsin, creating dual functionality: immunomodulation + CNS delivery. This immune-neural bridge is a defining feature of Selank's pharmacology.

Q3: How does Selank differ from Semax?¶

Both are PGP-extended heptapeptides but from different parents. Semax (ACTH-derived) → melanocortin → BDNF/NGF → cognition. Selank (tuftsin-derived) → GABA/dopamine → anxiolysis. Complementary: Semax for cognition, Selank for anxiety.

Q4: Does Selank cause sedation?¶

No — a significant distinction from benzodiazepines. In animal models, Selank produces anxiolytic effects at doses that do not cause sedation, motor impairment, or amnesia. Attributed to modulation of endogenous GABA tone rather than direct receptor agonism.

Q5: What purity and QC is provided?¶

≥99% HPLC purity, ESI-MS identity, amino acid analysis. Pro-Gly-Pro extension verified by MS/MS fragmentation. Batch-specific COA included.

Key Research References¶

Reference	PMID	Key Finding
Kost NV et al. "The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity." Bull Exp Biol Med. 2001;131(4):315–317.	11550013	Selank inhibits enkephalin-degrading enzymes, prolonging endogenous opioid peptide activity as a mechanism for anxiolysis
Filatova EV et al. "Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission." Front Pharmacol. 2016;7:31.	26924987	Selank modulates GABAergic gene expression in brain regions associated with anxiety, providing molecular basis for anxiolytic effects

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	Stable; no special handling beyond standard peptide storage. 24 months at 2–8°C in desiccated environment, protect from light
Pro-Gly-Pro Stability	The C-terminal PGP tripeptide confers enhanced stability and CNS penetration (shared design feature with Semax)
Neutral pH (6.0–7.5)	Stable; recommended for reconstitution in sterile water or PBS
Reconstituted Solution	24 h at 2–8°C; aliquot and freeze at −20°C for extended use. Avoid repeated freeze-thaw

Source & Purchase¶

For research-grade SELANK and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

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